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Almost half were coauthored with university researchers allergy shots lymphoma best order for claritin, and 12% were coauthored with federal agency researchers allergy treatment medication purchase claritin online now. Venture Capital Investment Supports the Commercialization of Emerging Technologies Access to financing is an essential component of the translation of inventions to innovations, both for new and growing firms. The difficulty of entrepreneurs obtaining financing contributes to the "valley of death," the inability of new and nascent firms to obtain financing to commercialize their inventions and technology. Venture capital investment also supports product development and marketing, company expansion, and acquisition financing. Four industries-software as a service, mobile, life sciences, and e-commerce-received the largest amount of U. Venture capital investment in China soared from $3 billion in 2013 to $34 billion in 2016, the fastest increase of any economy. Economic Impacts of Innovation Are Indirectly Measured, and Show Slowing Growth Impacts of innovation are understood in multiple ways, and economic indicators are a partial but quantifiable measure. It shows declining growth in the United States compared with the 2000s and earlier decades. Small, fast-growing firms in the United States, which are a measure of entrepreneurship and its associated job growth, have shown a declining rate of new firm formation since the early 2000s. Introduction Invention, knowledge transfer, and innovation are distinct but interrelated components of a complex system for transforming creativity and knowledge from S&E into benefits to society and the economy. Scientific discovery, as extended and amplified by applied research and development, increases the storehouse of knowledge available for further transformation. It requires indicators on actors, as individuals and through institutions that include businesses, government, academia, and nonprofit institutions. Inputs to innovation also include physical capital and infrastructure, both public and private, intangible capital, and publicly available knowledge. Innovation incidence provides an indicator of commercialization through the business sector. Beyond incidence, indicators of the impact of innovation presented here focus on two economic impacts, productivity growth and firm growth. Chapter Overview Invention brings something new into being and has a practical bent-the production of a new process or product that is potentially useful, previously unknown, and nonobvious. Invention contrasts with the focus of scientific research that leads to discovery-knowledge about existing phenomena that previously were unknown. In practice, inventions and scientific discovery often interact with each other: solving a practical problem may require the application of basic science not yet discovered, whereas scientific discovery may yield unanticipated applications that lead to potentially useful products and processes. In this chapter, we present data on inventions as represented by patents, along with information about their sources. This transfer can occur freely or through exchange, and deliberately or unintentionally. Innovation: the implementation of a new or significantly improved product (good or service) or process, a new marketing method, or a new organizational method in business practices, workplace organizations, or external relations. Innovation activities: All scientific, technological, organizational, financial, and commercial steps that actually lead, or are intended to lead, to the implementation of innovations. Economic impacts of innovation: the effects of innovations and innovation activities on business activities, economic output, employment, and standard of living. The transition from potential to realized usefulness for discoveries and inventions generally involves other actors besides scientists, engineers, and inventors. The discoveries and inventions must somehow be envisioned as useful and then adapted and adopted into practice and into circulation in the economy. This process frequently involves the transfer of science and technology (S&T) to businesses, government entities, universities, other organizations, and individuals for further development and eventual commercial and otherwise useful applications. Indicators for these activities include licensed inventions, citations, cooperative agreements, and collaborations. Other aspects of this transfer take place directly between individuals as they interact at work and less formally. Although harder to identify, this less formal or tacit transfer of technical knowledge is also an important dimension. The creation of new products and processes through innovation is a key goal for many nations. Many countries envision enhancing firm-based innovation and entrepreneurship as key paths toward those goals. These paths intersect as entrepreneurs start new firms that create new products and introduce new processes.

The prevalence of user innovation and free innovation transfers: Implications for statistical indicators and innovation policy allergy medicine for adults order claritin with mastercard. Report prepared for the Panel on Developing Science allergy shots weight gain buy claritin on line amex, Technology, and Innovation Indicators for the Future, National Academies of Science. Ivory Tower and Industrial Technology Transfer Before and After the Bayh- Dole Act. The economic nature of knowledge embodied in standards for technology-based industries. Objectives, characteristics and outcomes of university licensing: A survey of major U. Part B: Ranked list of organizations with 40 or more patents, as distributed by the year of patent grant and/or the year of patent application filing granted: 01/01/2015­12/31/2015. This appendix explains the methodological and statistical criteria used to assess possible data sources for inclusion in Indicators and to develop statements about the data. It also provides basic information about how statistical procedures and reasoning are applied. This appendix has four main sections, a glossary, and information on viewing the data sources for this report. The first section describes the considerations that are part of the selection process for information to be included in Indicators. The third section discusses factors that can affect accuracy at all stages of the survey process. The fourth section discusses the statistical testing used to determine whether differences between sample survey-based estimates are statistically significant-that is, greater than could be expected by chance. Selection of Data Sources Information is available from many sources, and it can vary in substantial ways. Data should represent the entire national or international populations of interest and should reflect the heterogeneity of those populations. Data should be also available for the subdomains of interest covered in Indicators. Data should include indicators central to the functioning of the science and technology enterprise. Survey methods used to collect data should provide sufficient assurance that survey estimates are robust and that statements based on statistical analysis of the data are valid and reliable. Nonsurvey data, such as administrative records, or data from other third-party sources should similarly be assessed for quality-that is, fitness for use. Data have validity if they accurately measure the phenomenon they are supposed to represent. Data have reliability if similar results would be produced if the same measurement or procedure were performed multiple times on the same population. Data are accurate if estimates from the data do not widely deviate from the true population value. Unless otherwise indicated, these data are representative of the nation as a whole and of the demographic, organizational, or geographic subgroups that constitute it. For data collected by governments in other countries and by nongovernment sources, including private survey firms and academic researchers, methodological information is examined to assess conformity with the criteria that U. Government statistical agencies in the developed world cooperate extensively both in developing dataquality standards and in improving international comparability for key data, and these agencies ensure that the methodological information about the data generated by this international statistical system is relatively complete. Often, methodological information about data from nongovernmental sources and from governmental agencies outside the international statistical system is less well documented. These data must meet basic scientific standards for representative sampling of survey respondents and for adequate and unbiased coverage of the population under study. The resulting measurements must be sufficiently relevant and meaningful to warrant publication despite methodological uncertainties that remain after the documentation has been scrutinized. Many data sources that contain pertinent information about a segment of the S&E enterprise are not cited in Indicators because their coverage of the United States is partial in terms of geography, incomplete in terms of segments of the population, or otherwise not representative.

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Describe indications for and perform adjustable sutures in more complicated cases (eg allergy testing vials order cheapest claritin and claritin, thyroid ophthalmopathy) allergy shots changed my life buy cheapest claritin. Describe and manage more complex complications of strabismus surgery (eg, globe perforation, corneal dellen, inclusion cysts, endophthalmitis, overcorrection, undercorrection). Perform more complex strabismus procedures (eg, Faden sutures, posterior myopexy, Yokoyama muscle union, "Y" splitting). Describe basic principles of retinal anatomy and physiology (ie, basic retinal and choroidal anatomy, retinal and choroidal physiology), with emphasis on macular anatomy and physiology. Describe pathological anatomy, physiopathology, and clinical pictures of the most common vascular diseases:** a. Describe features of different types of retinal detachment (ie, rhegmatogenous, tractional, exudative). Describe typical features of retinitis pigmentosa, main macular dystrophies (eg, Stargardt, Best, cone dystrophy), and other hereditary pathologies. Describe basic principles of laser photocoagulation (eg, laser response to change in power, duration, and spot size) and photodynamic therapy for retinal treatment. Diagnose, evaluate, and treat (or refer) postoperative/posttraumatic endophthalmitis. Perform slit-lamp biomicroscopy with precorneal lenses, 3-mirror contact lenses, or other wide-field contact lenses. Describe the fundamentals of retinal electrophysiology and basic ophthalmic echography. Diagnose, evaluate, treat (or refer) the following retinal vascular diseases:** a. Describe the findings of major studies in vascular retinal diseases, including the following:** a. Describe the fundamentals of, evaluate, and treat (or refer) peripheral retinal diseases and vitreous pathologies (eg, vitreous hemorrhage, posterior vitreous detachment, retinal tears, giant retinal tears, lattice degeneration with atrophic holes). Describe the techniques for retinal detachment repair, including indications, mechanics, instruments, basic techniques, and surgical adjuvants, including heavy liquids, expandable gases, and silicone oil for the following: a. Diagnose, evaluate, treat, and classify open and closed globe trauma (eg, Birmingham Eye Trauma Terminology System). Describe, evaluate, and treat (or refer) postoperative/posttraumatic choroidal detachments and sympathetic ophthalmia. Describe, recognize, and evaluate hereditary pathologies, such as juvenile retinoschisis and choroidal dystrophies (eg, choroideremia, gyrate atrophy). Describe the indications/complications for and perform basic laser treatment for diabetic retinopathy (eg, panretinal photocoagulation, macular grid). Perform ophthalmoscopic examination with contact lenses, including panfunduscopic lenses. Diagnose the presence of pigment granules in the anterior vitreous (ie, Shafer sign) during a retinal detachment or retinal break. Interpret basic echographic patterns (eg, rhegmatogenous retinal detachment, tractional retinal detachment, posterior vitreous detachment, choroidal detachment, intraocular foreign body). Perform fundus drawings of the retina, showing vitreoretinal relationships and findings. Describe indications, techniques, and complications of pars plana vitrectomy and scleral buckling. Perform (or assist during) vitreous tap and intravitreal antibiotic injections for the treatment of endophthalmitis. Perform subtenon injections of triamcinolone acetonide for the treatment of macular edema. Apply into clinical practice the most advanced knowledge of retinal anatomy and physiology (eg, surgical anatomy). Evaluate and diagnose complex cases of retinal detachment (eg, acute retinal necrosis, proliferative vitreoretinopathy). Diagnose and manage (or refer) complex trauma cases (eg, chorioretinitis sclopetaria, intraocular foreign body, shaken baby syndrome). Diagnose hereditary vitreoretinal degenerations (eg, Stickler syndrome, Wagner syndrome, Goldmann-Favre degeneration). Describe the treatment algorithm for each specific retinal condition, with special emphasis on pros and cons.

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African American and Native American populations also grew allergy symptoms roof of mouth claritin 10 mg with mastercard, but unlike Latinos allergy symptoms 6 days order cheap claritin line, Asians, and multiracial populations, they did not increase their relative share of the population. The non-Hispanic white population grew slightly, but other groups are gaining population so much more rapidly that the share of the population that is white is quickly decreasing. Rising inequality and stalled mobility As our nation continues to grow its demographic diversity, it is hardening in terms of economic inequality and social mobility, with communities of color often stuck at the bottom of the economic ladder. News reports, academic research, and increased social discontent-manifested by the Occupy movement-all attest to the rise in inequality in America. People of color, especially blacks, were 10 All-In Nation: An America that Works for All America in 2050 what will America look like in 2050? According to these projections, sometime in the early 2040s, non-hispanic whites will become a minority of our population. By 2050 they will be only 47 percent, with communities of color combining to form a solid 53 percent majority. But since this high-water mark for the middle class in the mid-1970s, incomes have essentially stagnated-just as people of color began at last to enjoy the benefits of equal opportunity in our economy and our society. Income inequality is currently at its highest level since the 1920s,7 and wealth inequality is even worse. Since 1979 the incomes of the top 1 percent of households have risen by an astounding 275 percent, while incomes for the middle 60 percent have risen about 40 percent, and incomes for the bottom 20 percent have risen a paltry 18 percent. Household income for whites is more than double that for African American and Latino households, and white family wealth is 20 times higher than that of African American families and 18 times higher than that of Latino families. Poverty rates are also high for many Asian subgroups such as the Hmong, Cambodians, Laotians, and Vietnamese. People of color are more likely to live in underserved neighborhoods that do not provide the good jobs, quality schools, retail options, parks, transportation, and services essential to live healthy lives and succeed economically. Inequality places our economy and democracy at risk Growing inequality runs counter to our identity and values as Americans. As inequality has spiked, there is growing concern that such high levels of inequality not only deprive those at the bottom of having a fair shot, but put the economy as a whole at a disadvantage. Recent reviews of the economics literature on inequality and growth find a growing academic consensus Creating an All-In Nation 13 that inequality has a negative impact on economic growth. The workforce is diversifying much more quickly than the overall population, yet people of color face many barriers to gaining the skills and education they need to maximize their participation and contributions. Rising inequality also undermines the fundamental American value of upward mobility. As Alan Krueger, chairman of the White House Council of Economic Advisers, argues, rising income inequality corresponds directly with lower economic mobility. Diversity drives the innovation process that is so fundamental to economic progress. Research finds that teams of diverse individuals, for example, are better at solving problems and coming up with new ideas. Companies with more diverse workforces have higher revenues, more customers, higher returns on equity and assets, and a greater market share. Communities of color are also starting new businesses at a rapid rate-despite lingering barriers to accessing low-cost capital, contracts, mentorship, and technical expertise. Between 2002 and 2007 the number of businesses owned by blacks, Latinos, and Asians grew more than three times as fast as white-owned businesses, and revenues grew more than twice as fast. A multilingual and multicultural population can help entrepreneurs, companies, and organizations communicate with, understand, and respond to potential customers, suppliers, and collaborators across the globe. And immigrant entrepreneurs are helping the United States meet its goals to increase exports, thanks to their ties to markets in their native countries. For long-term economic and social success, we must create a society with rising opportunity for all- black, white, Latino, Asian, and Native American; Creating an All-In Nation 15 rich, poor, and middle class alike. This will require taking steps to better educate our people and prepare our workers for global competition, and create the high-quality, high-wage jobs that are fundamental to shared prosperity. And it will require reorienting the public, private, and nonprofit sectors toward the task of giving all people a fair and equal shot in life regardless of their family background or historic patterns of exclusion. Fortunately, this is not a new task for America and we have many traditions and political values to draw upon. Since 1776 when Thomas Jefferson, Benjamin Franklin, and John Adams first proposed a national motto to the Second Continental Congress, America has been guided by the principle e pluribus unum, or "out of many, one. The message of the proposed national seal and motto was clear: the United States is a nation of distinct people from distinct regions united in the common cause of securing liberty and opportunity for all.

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Rosaceae (Rose Family) Cons/Econote: the distribution of this species in Maryland is enigmatic best allergy medicine 2014 discount 10 mg claritin amex. Historically this species has been reported as far west as Washington County (Shreve et al allergy treatment alternative buy genuine claritin line. This species occupies a wide range of geological substrates from strongly acid to ultramafic. Habitat at the largest known population is unremarkable and there appears to be much habitat available for the species indicating perhaps that habitat and survey prescriptions need re-evaluation. Additionally, the Service has noted broad fluctuations in population size that are not associated with changes in habitat. Agrimonia striata Michaux Woodland Agrimony Rosaceae (Rose Family) Cons/Econote: Endangered by habitat loss and displacement by invasive species. Locally abundant and comprising distinctive shrubland and woodland natural communities along tidal rivers and occasionally old millponds (Harrison and Stango 2003). The species is particularly susceptible to salt water intrusion (Schrader & Gallagher 2003), thus, past hurricanes and accompanying storm surge may be responsible for the current distribution. Habitat: Ecotones between fresh tidal marshes and tidal swamps, open-canopy Atlantic white cedar swamps. As a matter of coincidence, specimens have not been collected on the Somerset County side of Dividing Creek but the plant is abundant on the Worcester County side. Rediscovered on Assateague Island in 1998 after 31 years of absence (Tyndall et al. Amelanchier humilis Wiegand Running Shadbush G5 S1 T Rosaceae (Rose Family) Taxnote: A widespread species in the northeastern U. Cons/Econote: Threatened by competition and displacement by non-native, invasive shrubs, particularly Lonicera maackii. Amelanchier nantucketensis Bicknell Nantucket Shadbush G3Q S1 T Rosaceae (Rose Family) Taxnote: A widespread tetraploid (Burgess et al. Cons/Econote: Threatened by competition and displacement by invasive species and habitat alteration. Cons/Econote: Intolerant of shade, Maryland plants are restricted to a narrow zone of (chiefly) acidic sandstone glades. Global Rank G5 State State Federal Rank Status Status S2 Amianthium muscitoxicum (Walter) A. Cons/Econote: Upgraded from the Watchlist (S3) in 1999 based upon observed declines in range and population size due to heavy browse by white-tailed deer, and encroachment of invasive species. Ammannia latifolia Linnaeus Koehne Ammannia G5 S2 Lythraceae (Loosestrife Family) Cons/Econote: Recent surveys have failed to find this species in previously occupied habitat. Saltwater intrusion into baymouth barrier wetlands (Sipple 1982) is suspected to be associated with the decline at one site; however, other sites that are clearly brackish are extant. Amphicarpum amphicarpon (Pursh) Nash Blue Maidencane G4 S3 Poaceae (Grass Family) Syn: Amphicarpum purshii Kunth Cons/Econote: An Atlantic Coastal Plain endemic, restricted to the lower Eastern Shore in Maryland but often locally abundant. Habitat: Sandy soils, frequent in clearings under powerlines and edges of pine flatwoods. Krause Chaffweed Primulaceae (Primrose Family) Syn: Centunculus minimus Linnaeus Lysimachia minima (L. Cons/Econote: An irregularly occurring but widespread (in North America) low annual plant apparently very rare in the eastern U. Pearly Everlasting Asteraceae (Aster Family) Habitat: Dry to moist gravelly or sandy soils, old fields and clearings. Cons/Econote: Endemic to the southern and central Appalachians; the status of this species in Maryland has not been determined with precision. Flw: early May; Fr: June Angelica atropurpurea Linnaeus Apiaceae (Carrot Family) Cons/Econote: Known from a single collection dated 1941. Global Rank G4 State State Federal Rank Status Status S1 E Antennaria solitaria Rydberg Single-head Pussytoes G5 S2 T Asteraceae (Aster Family) Cons/Econote: Known from a series of isolated populations, often in low numbers, and with few protected populations. Habitat: Oak-beech-heath bluffs and woodlands often on steep, actively eroding slopes and occasionally on tip-up mounds of fallen trees. Schouten & Veldkamp Vanilla Grass, Holy Grass Poaceae (Grass Family) Syn: Hierochloe odorata (Linnaeus) P.

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